The Houston Texans have stumbled out of the gates and look to earn their first win of the season when they battle the Tennessee Titans (+7) in an AFC South matchup in one of several must-win situations to highlight the NFL Week 5 schedule. Another team in need of a win is the Los Angeles Rams, a Super Bowl pick that finds themselves two games out in the highly-competitive NFC West race. The Rams avoided a 1-3 start with a 24-20 win over the Philadelphia Eagles this past Sunday.
The Rams enter as 3.5-point home favorites when they host the the Buffalo Bills on 'Monday Night Football.' Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: There are a number of intriguing matchups in Week 5, including 49ers vs. Seahawks (-3) in another game involving NFC West foes. Other top games include Ravens vs.
Falcons (-3) on 'Sunday Night Football,' with Lamar Jackson (ankle) out, Bears vs. Packers (+1.5) and Broncos vs. Before locking in any Week 5 NFL picks, be sure to see the NFL parlay and betting advice from SportsLine's proven computer model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns.
Now, the model has scoured the Week 5 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of nearly 25-1. You can only see the model's Week 5 NFL picks at SportsLine.
Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: After simulating every game 10,000 times, the model backs the Texans and Titans to combine for 45 points as the Over 38 hits in 65% of simulations at betting apps on Sunday at 1 p.m. The Over has cleared in two of the last four head-to-head matchups. It has also cleared in six of the last 10 Houston, and five of the last nine Tennessee games.
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