A spot in the American League Championship Series is on the line when the Chicago White Sox battle the Cleveland Guardians in Game 5 of the ALDS on Saturday night. Cleveland evened the series with a 9-5 win on Thursday. The White Sox (84-78), who finished second in the AL Central, are 38-45 on the road in 2026, including the postseason.
The Guardians (85-77), who won the AL Central, are 41-42 at home. Chicago is expected to start right-hander Sean Burke (11-7, 3.34 ERA), while Cleveland is expected to counter with right-hander Gavin Williams (14-8, 3.76 ERA). Visit our Kalshi promo code review and get a $55 trading bonus after $25+ in trades with the Kalshi promo code CBSSPORTS55: First pitch from Progressive Field in Cleveland is set for 8 p.m.
The White Sox are 9-8 versus the Guardians over the 2026 regular and postseason. Cleveland is a -142 favorite on the money line (risk $142 to win $100) in the latest White Sox vs. Guardians odds, with Chicago at +119, while the over/under is 7.5.
The Over has hit in six of the last seven matchups between the teams. Before making any Guardians vs. White Sox picks, be sure to see the White Sox vs.
Guardians predictions and betting advice from SportsLine's proven computer model. SportsLine's model simulates every MLB game 10,000 times and enters the divisional round of the 2026 MLB playoffs on a 31-25 run on all top-rated MLB money-line picks at betting sites, returning more than $900 for $100 players. Anyone following its picks at MLB betting sites could have seen strong returns.
Now, the model has set its sights on White Sox vs. Guardians and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks.
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