This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility: Octopuses, squid and cuttlefish, collectively known as coleoid cephalopods, have evolved exceptionally large and elaborately structured nervous systems capable of complex behaviors such as problem-solving and rapid camouflage. A new study by scientists at the University of Vienna suggests that the origins of this complexity may lie not just in the genes themselves, but in how the genome is organized in 3D.
The researchers found that ancient, extensive reorganization of the genome altered how DNA is arranged inside the cell. These shifts brought previously distant regions of DNA into contact, changing the way genes are regulated. Understanding this process could change how we think about how new traits emerge during evolution.
The findings are published in the journal Nature Communications. The team studied the 3D structure of the genome across octopuses, squid and cuttlefish, combining data on DNA structure with gene activity. "The genome isn't just a sequence of genes.
It's folded into a complex three-dimensional structure," said lead author Dr. "Understanding how that structure evolves is becoming increasingly important for understanding how new forms of biological complexity arise." In cephalopods, a large-scale burst of genome reorganization, which occurred hundreds of millions of years ago, dramatically reshuffled the genome and brought previously distant regions of chromosomes into close proximity. The researchers found that when regions of DNA are brought into contact, they can begin to interact and influence each other's activity.
Over time, these interactions can become embedded, forming increasingly interconnected regulatory networks. This process, described by the researchers as "regulatory entanglement," may allow genomes to generate new patterns of gene expression while maintaining essential functions. Not all aspects of genome structure appear to respond to genome reorganization in the same way.
The researchers found that large structural units of the genome, known as chromatin domains, remained largely stable over evolutionary time. In contrast, finer-scale connections known as chromatin loops were far more dynamic. These loops bring distant regions of DNA into contact.
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