This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility: Neurons in humans and other mammals express many exceptionally long genes, ranging from more than 100 kbp to more than 2 Mbp, that are important for forming synapses and neural circuits. In general, genetic information is read from DNA into RNA.
This process is called transcription. The longer a gene is, the more time it takes to read from beginning to end. In addition, gene expression must be regulated at several steps.
Neurons are therefore thought to require special mechanisms to read long genes accurately and stably, but the details of these mechanisms have remained unclear. In a new study published in Cell Chemical Biology, researchers from Ehime University focused on SFPQ, a protein that binds RNA. Using super-resolution microscopy and other approaches, they found that SFPQ uses long RNAs as scaffolds to form meshwork-like structures called condensates inside the cell nucleus.
Condensates are membraneless structures formed when particular molecules gather inside cells. The team also found that these condensates bring together many molecules involved in transcription—the reading of DNA into RNA—splicing, which joins the appropriate parts of newly made RNA, and regulation of chromatin, the structure that packages DNA. When SFPQ condensates could not form, extra-long genes were not read properly to the end, RNA splicing was impaired, and gene expression decreased.
These results suggest that SFPQ condensates act as a shared "workspace" that brings together several processes needed for exceptionally long genes to function properly. The study provides insight into the physical basis of the previously proposed "transcriptional elongation condensate" and offers a new way to understand gene regulation through the spatial organization of the nucleus. SFPQ and related proteins have also been linked to autism spectrum disorder (ASD) and amyotrophic lateral sclerosis (ALS).
In the future, studying abnormal expression of extra-long genes may help us better understand the mechanisms of neurodevelopmental and neurodegenerative disorders. Motoyasu Hosokawa et al, RNA-dependent SFPQ condensates coordinate multidimensional regulation of extra-long neuronal genes, Cell Chemical Biology (2026). DOI: 10.1016/j.chembiol.2026.06.004 Journal information: Cell Chemical Biology BA art history, MA material culture.
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