An exploratory remote pilot study of environmental risk factors for Lewy body dementia considering sex differences

Lewy body dementia (LBD), including Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), is a common dementia that currently lacks disease modification. While studies in Alzheimer’s and Parkinson’s diseases underscore the contribution of environmental factors with sex differences, knowledge on LBD environmental risk factors remains limited. We conducted an exploratory remote pilot survey, including data on residential history, chemical exposure, smoking, and alcohol use, for people with LBD (n = 130; 51 females, 79 males) and age-matched controls (n = 124; 64 females, 60 males).

Associations with LBD risk for each environmental factor were assessed in the overall cohort and stratified by sex and LBD subtype (DLB or PDD). Metal exposure was associated with a higher risk of LBD. Alcohol and smoking were associated with a higher risk, particularly for males; glue/adhesives and not living in the suburbs were associated with a higher risk, particularly for females.

Environmental factors likely play a role in LBD with potential sex differences. We thank the participants, Metin Ozlu, Hatice Ozlu, Fermin Garduño, Rosa Zander, and all Lewy body disease advocates for showing resilience, being an inspiration, and supporting research. This study was funded by the LBDA (Early Investigator Pilot Study Award, no specific grant number).

The funder had no role in the design, data analysis, and reporting of the study. For data collection, the funder assisted in advertising the study for recruitment and had no further role. Department of Neurology, University of Colorado Anschutz, Aurora, CO, USA Ece Bayram, Francesca R.

Holden Department of Neurosciences, University of California San Diego, La Jolla, CA, USA Ece Bayram, Reilly Costello, Hamidreza Ghodsi, Charlotte S. Rivera & Irene Litvan Department of Biostatistics and Informatics, University of Colorado Anschutz, Aurora, CO, USA Department of Neurology, Mayo Clinic, Rochester, MN, USA The authors declare no competing interests. Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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