Brain MR elastography metrics associated with alterations in learning and memory in people with HIV

High prevalence of HIV-associated neurocognitive impairment persists despite effective antiretroviral therapy. While conventional neuroimaging has been previously used to explain cognitive deficits in virally suppressed people with HIV (PWH), magnetic resonance elastography (MRE) offers a novel approach to quantify microstructural tissue coherence through brain biomechanics. This study investigated whether MRE-derived biomechanical metrics exhibit a pathological, group-specific relationship with cognitive performance in PWH, and compared their sensitivity against advanced diffusion MRI and peripheral biomarkers of neuronal injury and inflammation.

In a cross-sectional cohort of 27 virally suppressed PWH and 30 matched healthy controls, participants underwent comprehensive cognitive testing, multi-frequency MRE (measuring stiffness, viscosity, and strain), multi-shell diffusion MRI (including NODDI metrics), and blood sampling for plasma neurofilament light chain and glial fibrillary acidic protein. PWH exhibited significantly lower cognitive scores than controls, particularly in learning and memory. Although baseline mean values across imaging and peripheral biomarkers did not notably differ between the groups, a significant group-by-cognition interaction emerged exclusively for MRE parameters.

Specifically, in PWH, elevated viscosity and reduced strain correlated with better attention, whereas lower viscosity and strain correlated with poorer memory. These biomechanical-behavioral relationships were absent in healthy controls, and no notable interactions were observed for advanced diffusion metrics or blood biomarkers. Ultimately, brain biomechanics measured by MRE demonstrate greater sensitivity to altered cognitive function in PWH than advanced diffusion MRI and peripheral biomarkers, highlighting their potential as functional correlates of neurocognitive impairment that warrant further longitudinal validation.

Multi-frequency dual elasto-visco inversion Neurite Orientation Dispersion and Density Imaging National Institutes of Health, R21NS113674, R01 R01HL160229, German Research Foundation, BIOQIC GRK2260, CRC1540 EBM 460333672. Department of Neurology, University of Rochester, Rochester, NY, USA Abrar Faiyaz, Miriam Weber, Meera V. Singh, Md Nasir Uddin & Giovanni Schifitto Department of Microbiology and Immunology, University of Rochester, Rochester, NY, USA Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY, USA Irteza E.

Doyley, Md Nasir Uddin & Giovanni Schifitto Department of Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA Department of Imaging Sciences, University of Rochester, Rochester, NY, USA Department of Neuroscience, University of Rochester, Rochester, NY, USA The authors declare no competing interests. All protocols were reviewed and approved by the Research Subjects Review Board (RSRB) at the University of Rochester. All participants signed a written consent form.

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