While the 2026 college football season got a hearty appetizer with Week 0, the main course will be served with the Week 1 college football schedule. There are 90 games involving FBS teams on the slate, with several intriguing non-conference matchups. Lane Kiffin makes his LSU debut versus Clemson on Saturday, which has the Tigers of Baton Rouge as 10-point home favorites per the latest Week 1 college football odds.
Then on Sunday, the only ranked contest of the weekend occurs with Kiffin's former squad in No. 9 Ole Miss vs. No. 24 Louisville (+6.5). Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Other top non-conference games on Saturday include UCLA vs.
Cal (+2.5), which used to be a Pac-12 rivalry, as well as Baylor vs. Auburn (-7.5) at a neutral site in Atlanta. Wisconsin is on Sunday at Lambeau Field, while SMU at Florida State (+3) concludes the weekend on Monday.
Before locking in any Week 1 college football picks, be sure to see the latest college football predictions from SportsLine's proven model. The model simulates every FBS game 10,000 times. It is on a 32-19 run on top-rated CFB money-line picks on betting sites since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal.
Anybody following its college football betting picks could have seen strong returns. Now, it has turned its attention to the latest college football odds for Week 1 and locked in picks for every FBS matchup. Head here to see every pick.
Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS: One of the top Week 1 college football picks the model is recommending for best betting apps: Auburn (-7.5, 59.5) covers against Baylor in a 3:30 p.m. ET kickoff in the debut for coach Alex Golesh at Auburn. No team performed worse versus the line than the Bears last year, going 2-10 ATS.
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