The Week 3 college football schedule features one game -- Syracuse vs. Pittsburgh -- on Thursday and two FBS matchups -- Miami vs. Wake Forest and Texas Tech vs.
One of the most anticipated games of the season comes on Saturday as Ole Miss hosts Lane Kiffin and LSU in a top-10 matchup. The atmosphere in Oxford should be raucous as Kiffin returns to the program he bolted from before last season's College Football Playoff began. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades: The latest Week 3 college football lines list LSU as a 3-point road favorite.
Other college football odds of note include Alabama (-19.5) vs. Florida State, Florida (-2.5) vs. Auburn and Clemson (-3.5) against North Carolina.
Before locking in any Week 3 college football picks on those games or others, be sure to see the latest college football score predictions from SportsLine's proven model. The model simulates every FBS game 10,000 times. It is on a 33-21 run on top-rated CFB money-line picks on betting sites since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal.
Anybody following its picks on college football betting sites could have seen strong returns. Now, it has turned its attention to the latest college football odds for Week 3 and locked in picks for every FBS matchup. Head here to see every pick.
Visit our Kalshi promo code review and get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS: One college football score prediction for the Week 3 college football schedule at the best betting apps: The model projects that Alabama beats Florida State 33-20 in a 3:30 p.m. ET kickoff at Bryant-Denny Stadium in Tuscaloosa. That makes FSU (+19.5) the play against the spread as the Seminoles cover 66% of the time, while the Over (49.5) clears 53% of the time in the simulations.
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