Tottenham Hotspur Stadium in London is a host for the NFL in Week 4 when Marcus Mariota and the Washington Commanders take on Daniel Jones and the Indianapolis Colts in the first NFL London game of the season. Each team comes to England after winning the first games of the season in Week 3; the Colts got past the Texans 19-17 while the Commanders surprised the reigning Super Bowl champion Seahawks in their first game without star quarterback Jayden Daniels. Daniels has been ruled out as he continues recovery from a dislocated elbow.
Receiver Terry McLaurin (hamstring) was added to the injury report as questionable on Friday. Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after depositing $10: Kickoff is set for 9:30 a.m. ET from Tottenham Hotspur Stadium in London.
Commanders odds have Indianapolis as a 4.5-point favorite. The over/under for total points scored is 47.5. Both teams are 2-1 against the spread so far in 2026.
Before making any Colts vs. Commanders picks, be sure to see the 2026 NFL London Game predictions from SportsLine projection model. The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on betting sites on top-rated NFL picks since its inception.
The model entered Week 4 of the 2026 NFL season on a 54-43 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns. Now, the model has zoned in on Colts vs.
You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Commanders vs. Colts: New to sports trading?
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