The endocannabinoid system functions as a gatekeeper of motivational processes. Here, we show that CRISPR-mediated inhibition of the degrading enzyme for the brain endocannabinoid, 2-AG, at ventral tegmental area GABAergic interneurons promotes social, but not food-maintained, operant responding. These results reveal a region-specific role for endocannabinoid signaling in social motivation.
This is a preview of subscription content, access via your institution Receive 13 print issues and online access We are sorry, but there is no personal subscription option available for your country. Prices may be subject to local taxes which are calculated during checkout The data that support the findings of this study are available from the corresponding author upon reasonable request. Kirkbride JB, Anglin DM, Colman I, Dykxhoorn J, Jones PB, Patalay P, et al.
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