The NFL is coming off one of its craziest weeks in recent memory, as Week 3 tied a league record for the number of one-score games. Judging by the Cleveland Browns upset win over the Pittsburgh Steelers on Thursday, Week 4 promises to continue the madness as we flip the calendar to October and close out the first month of the regular season. Of course, between work, daily chores, and craziness that is life, it's hard to keep pace with all that's happening across the NFL.
For instance, you might not have realized that a massive trade popped up midweek, in which the Cowboys acquired standout corner Joey Porter Jr. from the Steelers. Or, from a scheduling standpoint, we have early morning football on Sunday, with the Commanders and Colts kicking off from London. So, as you get ready for another Sunday of full-fledged NFL action, we want you to be as informed as possible before you line up any wagers you may make.
With that in mind, here's a look at some last-minute Week 4 picks, including five best bets. NFL odds courtesy of DraftKings Sportsbook. Both clubs enter Week 4 after rather demoralizing losses on the road.
Case Keenum sliced Philly up on "Monday Night Football," and they now have to turn around and square off against the Matthew Stafford-led Rams on a short week. Meanwhile, L.A. lost a heartbreaker in Denver, which dropped the preseason "superteam" to 1-2 through the first three weeks. Each of these teams has yet to live up to their lofty expectations so far this year, but I think the Rams are in a better spot to pull off the win here, especially with the return of wideout Puka Nacua.
At first glance, you might be eager to take the Eagles as a home dog, but they've historically not been kind to bettors in this setting. Since 2021 (Sirianni's first season as head coach), Philadelphia is 0-5 straight up (1-4 ATS) as a home underdog. When watching them this season, it's clear their offense is still a work in progress.
The Eagles have yet to score in the first quarter this season (the only team in the NFL yet to score) and have the highest three-and-out rate (29%) since 2025. When you pair that with a defense that has yet to generate a turnover and has registered just three sacks, there's an opportunity for the Rams to get out to an early lead and never look back. As we saw on Monday night, when you get the Eagles into a pass-heavy game script, it's not exactly "The Greatest Show on Turf," and they'll try to win in Week 4 without top wideout DeVonta Smith (hamstring).
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