A rare Week 1 conference battle takes place on Labor Day as the No. 19 SMU Mustangs visit the Florida State Seminoles. The Noles (1-0) kicked off their season with a Week 0 victory over New Mexico State by a score of 34-17. FSU went 5-7 overall last season, including a 2-6 mark in the ACC.
The Mustangs (0-0) went 9-4 a year ago, with a 6-2 conference mark, as they finished 2025 ranked 12th in the nation. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Kickoff is at 7:30 p.m. ET from Doak Campbell Stadium in Tallahassee, Fla.
SMU won the only prior meeting, which came in 2024. The Mustangs are 2.5-point favorites in the latest SMU vs. Florida State odds, while the over/under is 53.5 points.
Before making any Florida State vs. SMU picks, check out the SMU vs. FSU predictions from SportsLine expert Josh Nagel.
Nagel is a Reno-based analyst and radio host who has worked in the sports handicapping industry for more than 20 years. SportsLine's assistant managing editor has covered the wagering industry on a variety of platforms and has won numerous sports handicapping contests with his college football betting picks. Nagel is 8-3 (+485) over his last 11 picks involving SMU at betting sites.
Now, Nagel has analyzed SMU vs. Florida State and revealed his best bets. You can visit SportsLine now to see his picks.
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