Primary and metastatic brain tumours are associated with poor clinical outcomes, largely owing to limited therapeutic advances and an incomplete understanding of brain tumour biology. Increasing evidence suggests that microbial communities play an important part in shaping systemic immunity and tumour biology. Microbes and microbial by-products from the gut and oral cavity can influence the central nervous system through the gut–oral–brain axis, providing potential mechanisms by which distant microbes shape the brain tumour microenvironment.
A growing body of literature has identified distinct gut and oral microbial signatures associated with brain tumours and demonstrated that microbiota modulation can influence tumour growth and treatment response in preclinical models. In addition, emerging clinical data indicate that primary and metastatic brain tumours can harbour intracellular microbial elements. In this Review, we summarize current knowledge on the roles of the gut and oral microbiota and intratumoural microbial elements in brain tumour biology and treatment response.
We present the technical challenges inherent to microbial studies in brain tumours due to low biomass and the high risk of contamination, and discuss key clinical, experimental and computational considerations needed for rigorous experimental design and standardized methodologies. Last, we discuss translational opportunities and future directions for moving the field towards clinical impact. This is a preview of subscription content, access via your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription Receive 12 print issues and online access Prices may be subject to local taxes which are calculated during checkout Ostrom, Q.
CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013-2017. Neuro Oncol. 22, iv1–iv96 https://doi.org/10.1093/neuonc/noaa200 (2020). Article PubMed PubMed Central Google Scholar Schaff, L.
Glioblastoma and other primary brain malignancies in adults: a review. JAMA 329, 574–587 https://doi.org/10.1001/jama.2023.0023 (2023). The epidemiology of glioma in adults: a “state of the science” review.
Neuro Oncol. 16, 896–913 https://doi.org/10.1093/neuonc/nou087 (2014). Article CAS PubMed PubMed Central Google Scholar Lamba, N., Wen, P. Epidemiology of brain metastases and leptomeningeal disease.
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