The 14th-ranked USC Trojans look to make it two in a row to start the season when they battle the Fresno State Bulldogs in a Week 1 college football non-conference matchup on Friday night. Fresno State, now a member of the Pac-12, finished tied for fifth with Hawaii at 5-3 in the Mountain West and were 9-4 overall in 2025. USC, which tied for fourth in the Big Ten with Michigan at 7-2, were 9-4 overall a year ago.
USC has won five of six all-time meetings, including a 45-17 win in 2022. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Kickoff is set for 9 p.m. ET at Los Angeles Memorial Coliseum.
The Trojans are 21.5-point favorites in the latest Fresno State vs. The over/under for total points is 51.5. Before making any Fresno State vs.
USC picks, check out the Fresno State vs. USC predictions from the SportsLine Projection Model. The model simulates every FBS game 10,000 times.
It is on a 32-19 run on top-rated CFB money-line picks on betting sites since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal. Anybody following its college football betting picks could have seen strong returns. Now, the model has set its sights on Fresno State vs.
You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for USC vs. Fresno State: New to sports trading?
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