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Louisville vs. Ole Miss prediction, odds, time: 2026 college football picks, best bets by expert on 22-9 run

Louisville vs. Ole Miss prediction, odds, time: 2026 college football picks, best bets by expert on 22-9 run

cbssports.com 06.09.2026 16:52 2 views
SportsLine's Zack Cimini reveals his picks for the Louisville Cardinals vs. Ole Miss Rebels matchup on Sunday

Ole Miss opens the post-Lane Kiffin era with its high-powered offense against a defense-first Louisville squad in a featured Week 1 college football matchup. Pete Golding remains in charge after steering the Rebels to the College Football Playoff semifinals once Kiffin left for LSU, and quarterback Trinidad Chambliss is back after receiving a sixth year of eligibility. Louisville has posted 9- or 10-win seasons in each of Jeff Brohm's three years at the helm, and Lincoln Kienholz, the 2023 national high school player of the year, finally gets his first career start after two seasons as a backup at Ohio State.

Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here: Kickoff for the neutral-site game is set for 7:30 p.m. ET at Nissan Stadium in Nashville. The Rebels are 6.5-point favorites in the latest Louisville vs.

Ole Miss odds, while the over/under is 55.5. Before making any Louisville vs. Ole Miss picks, check out the college football predictions from expert Zack Cimini.

A Las Vegas handicapper, Cimini has returned a profit across multiple sports. Over the past three college football seasons, Cimini is 91-68-2, returning $1,420 to $100 bettors. He also enters the 2026 college football season on a 22-9 run (+1068) over his last 31 ATS picks.

Anybody following his college football betting picks at sportsbooks and on betting sites could have seen huge returns. Now, Cimini has analyzed Louisville vs. Ole Miss from every angle.

You can visit SportsLine now to see his picks. Here are the FBS college football odds and trends for Ole Miss vs. Louisville: New to sports trading?

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